PUBLICATIONS

Google Scholar

My NCBI

Karp Lab Publications

daf-16/FOXO promotes the activity of ligand-bound DAF-12/NHR to coordinate dauer exit and post-dauer seam cell fate [preprint]

Wirick MJ*, Smith IT*, Olson BS*, Alessi AF, Galagali H, Lalk K*, Schmidt MN*, Ranke KJ*, Kim JK, Karp X.

bioRxiv [Preprint]. 2025. doi: 10.1101/2025.06.18.660181. PMID: 40666959 *CMU student.

hbl-1 does not contribute to the misexpression of an adult cell fate marker in daf-16 mutant dauer larvae

Wirick MJ*, Karp X.

MicroPubl Biol. 2025. doi: 10.17912/micropub.biology.001662. PMID: 40630193. *CMU student.

ets-10p::gfp expression is predictive of dauer formation in daf-16; daf-7 larvae

Lindsay JT*, Wirick MJ*, Karp X.

MicroPubl Biol. 2024. doi: 10.17912/micropub.biology.001358. PMID: 39502419. *CMU student.

An RNAi screen for conserved kinases that enhance microRNA activity after dauer in C. elegans

Roka Pun H*, Karp X.

G3. 2024 Jan 16. doi: 10.1093/g3journal/jkae007. PMID: 38226857. *CMU student.

Distinct daf-16 isoforms regulate specification of vulval precursor cells in Caenorhabditis elegans

Cuko L*, Cale AR*, Rambo L*, Knoblock M*, Karp X.

MicroPubl Biol. 2022. doi: 10.17912/micropub.biology.000706. PMID: 36575736. *CMU student.

ztf-16 is a novel heterochronic modulator that opposes adult cell fate in dauer and continuous life histories in Caenorhabditis elegans. [preprint]

Hansen MA*, Dahal A*, Bernstein TA*, Kohtz C*, Ali S*, Daul AL, Montoye EA*, Panzade GP, Alessi AF, Flibotte S, Vargas ML, Bourgeois J*, Brown CJ*, Kim JK, Rougvie AE, Zinovyeva A, Karp X.

bioRxiv. 2022. doi: 10.1101/2022.06.20.496913 . *CMU student.

daf-16/FOXO blocks adult cell fate in Caenorhabditis elegans dauer larvae via lin-41/TRIM71

Wirick MJ* (equal contribution), Cale AR* (equal contribution), Smith IT*, Alessi AF, Starostik MR, Cuko L*, Lalk K*, Schmidt MN*, Olson BS*, Salomon PM*, Santos A*, Schmitter-Sánchez A*, Galagali H, Ranke KJ*, Wolbert PA*, Knoblock ML*, Kim JK, Karp X.

PLoS Genet. 2021 Nov 15;17(11):e1009881. doi: 10.1371/journal.pgen.1009881. eCollection 2021 Nov. PMID: 34780472 . *CMU student.

Hormonal Regulation of Diapause and Development in Nematodes, Insects, and Fishes

Karp X.

Frontiers in Ecology and Evolution. 2021 September; 9:735924. doi: 10.3389/fevo.2021.735924.

***lin-41* controls dauer formation and morphology via lin-29 in *C. elegans***

Cale, AR*, Karp, X.

microPublication Biology. 2020. doi: 10.17912/micropub.biology.000323. *CMU student.

Working with dauer larvae

Karp X.

WormBook. 2018 Aug 9:1-19. doi: 10.1895/wormbook.1.180.1. PMID: 27417559.

**Fluorescent Beads Are a Versatile Tool for Staging Caenorhabditis elegans in Different Life Histories.**

Nika L*, Gibson T*, Konkus R*, Karp X.

G3 (Bethesda). 2016 Jul 7;6(7):1923-33. doi: 10.1534/g3.116.030163. PMID: 27172224. *CMU student.

Casein kinase II promotes target silencing by miRISC through direct phosphorylation of the DEAD-box RNA helicase CGH-1.

Alessi AF, Khivansara V, Han T, Freeberg MA, Moresco JJ, Tu PG, Montoye E*, Yates JR 3rd, Karp X, Kim JK.

Proc Natl Acad Sci U S A. 2015 Dec 29;112(52):E7213-22. doi: 10.1073/pnas.1509499112. Epub 2015 Dec 15. PMID: 26669440 . *CMU student.

Other Karp Publications

**Control of cell-fate plasticity and maintenance of multipotency by DAF-16/FoxO in quiescent Caenorhabditis elegans.**

Karp X, Greenwald I.

Proc Natl Acad Sci U S A. 2013 Feb 5;110(6):2181-6. doi: 10.1073/pnas.1222377110. Epub 2013 Jan 22. PMID: 23341633.

**Dauer larva quiescence alters the circuitry of microRNA pathways regulating cell fate progression in C. elegans.**

Karp X, Ambros V.

Development. 2012 Jun;139(12):2177-86. doi: 10.1242/dev.075986. PMID: 22619389

**Effect of life history on microRNA expression during C. elegans development.**

Karp X, Hammell M, Ow MC, Ambros V.

RNA. 2011 Apr;17(4):639-51. doi: 10.1261/rna.2310111. Epub 2011 Feb 22. PMID: 21343388.

**Effect of life history on microRNA expression during C. elegans development.**

Karp X, Hammell M, Ow MC, Ambros V.

RNA. 2011 Apr;17(4):639-51. doi: 10.1261/rna.2310111. Epub 2011 Feb 22. PMID: 21343388.

**The developmental timing regulator HBL-1 modulates the dauer formation decision in Caenorhabditis elegans.**

Karp X, Ambros V.

Genetics. 2011 Jan;187(1):345-53. doi: 10.1534/genetics.110.123992. Epub 2010 Oct 26. PMID: 20980238.

**A feedback circuit involving let-7-family miRNAs and DAF-12 integrates environmental signals and developmental timing in Caenorhabditis elegans.**

Hammell CM, Karp X, Ambros V.

Proc Natl Acad Sci U S A. 2009 Nov 3;106(44):18668-73. doi: 10.1073/pnas.0908131106. Epub 2009 Oct 14. PMID: 19828440.

Developmental biology. Encountering microRNAs in cell fate signaling.

Karp X, Ambros V.

Science. 2005 Nov 25;310(5752):1288-9. PMID: 16311325.

**Multiple roles for the E/Daughterless ortholog HLH-2 during C. elegans gonadogenesis.**

Karp X, Greenwald I.

Dev Biol. 2004 Aug 15;272(2):460-9. PMID: 15282161.

**Post-transcriptional regulation of the E/Daughterless ortholog HLH-2, negative feedback, and birth order bias during the AC/VU decision in C. elegans.**

Karp X, Greenwald I.

Genes Dev. 2003 Dec 15;17(24):3100-11. PMID: 14701877.

G2A is an oncogenic G protein-coupled receptor.

Zohn IE, Klinger M, Karp X, Kirk H, Symons M, Chrzanowska-Wodnicka M, Der CJ, Kay RJ.

Oncogene. 2000 Aug 10;19(34):3866-77. PMID: 10951580.

Activation of SPARC expression in reactive stroma associated with human epithelial ovarian cancer.

Brown TJ, Shaw PA, Karp X, Huynh MH, Begley H, Ringuette MJ.

Gynecol Oncol. 1999 Oct;75(1):25-33. PMID: 10502421

Ectopic expression of SPARC in Xenopus embryos interferes with tissue morphogenesis: identification of a bioactive sequence in the C-terminal EF hand.

Damjanovski S, Karp X, Funk S, Sage EH, Ringuette MJ.

J Histochem Cytochem. 1997 May;45(5):643-55. PMID: 9154151.

Funding