PUBLICATIONSGoogle ScholarMy NCBI Recent Publications Distinct daf-16 isoforms regulate specification of vulval precursor cells in Caenorhabditis elegansCuko L*, Cale AR*, Rambo L*, Knoblock M*, Karp X.microPublication Biology. 2022. doi: 10.17912/micropub.biology.000706 . *CMU student. ztf-16 is a novel heterochronic modulator that opposes adult cell fate in dauer and continuous life histories in Caenorhabditis elegans. [preprint]Hansen MA*, Dahal A*, Bernstein TA*, Kohtz C*, Ali S*, Daul AL, Montoye EA*, Panzade GP, Alessi AF, Flibotte S, Vargas ML, Bourgeois J*, Brown CJ*, Kim JK, Rougvie AE, Zinovyeva A, Karp X.bioRxiv. 2022. doi: 10.1101/2022.06.20.496913 . *CMU student. daf-16/FOXO blocks adult cell fate in Caenorhabditis elegans dauer larvae via lin-41/TRIM71Wirick MJ* (equal contribution), Cale AR* (equal contribution), Smith IT*, Alessi AF, Starostik MR, Cuko L*, Lalk K*, Schmidt MN*, Olson BS*, Salomon PM*, Santos A*, Schmitter-Sánchez A*, Galagali H, Ranke KJ*, Wolbert PA*, Knoblock ML*, Kim JK, Karp X.PLoS Genet. 2021 Nov 15;17(11):e1009881. doi: 10.1371/journal.pgen.1009881. eCollection 2021 Nov. PMID: 34780472 . *CMU student. Hormonal Regulation of Diapause and Development in Nematodes, Insects, and FishesKarp X.Frontiers in Ecology and Evolution. 2021 September; 9:735924. doi: 10.3389/fevo.2021.735924. lin-41 controls dauer formation and morphology via lin-29 in C. elegansCale, AR*, Karp, X.microPublication Biology. 2020. doi: 10.17912/micropub.biology.000323. *CMU student. Working with dauer larvaeKarp X.WormBook. 2018 Aug 9:1-19. doi: 10.1895/wormbook.1.180.1. PMID: 27417559. Fluorescent Beads Are a Versatile Tool for Staging Caenorhabditis elegans in Different Life Histories.Nika L*, Gibson T*, Konkus R*, Karp X.G3 (Bethesda). 2016 Jul 7;6(7):1923-33. doi: 10.1534/g3.116.030163. PMID: 27172224. *CMU student. Casein kinase II promotes target silencing by miRISC through direct phosphorylation of the DEAD-box RNA helicase CGH-1.Alessi AF, Khivansara V, Han T, Freeberg MA, Moresco JJ, Tu PG, Montoye E*, Yates JR 3rd, Karp X, Kim JK.Proc Natl Acad Sci U S A. 2015 Dec 29;112(52):E7213-22. doi: 10.1073/pnas.1509499112. Epub 2015 Dec 15. PMID: 26669440. *CMU student.Other Publications Control of cell-fate plasticity and maintenance of multipotency by DAF-16/FoxO in quiescent Caenorhabditis elegans.Karp X, Greenwald I.Proc Natl Acad Sci U S A. 2013 Feb 5;110(6):2181-6. doi: 10.1073/pnas.1222377110. Epub 2013 Jan 22. PMID: 23341633. Dauer larva quiescence alters the circuitry of microRNA pathways regulating cell fate progression in C. elegans.Karp X, Ambros V.Development. 2012 Jun;139(12):2177-86. doi: 10.1242/dev.075986. PMID: 22619389 Effect of life history on microRNA expression during C. elegans development.Karp X, Hammell M, Ow MC, Ambros V.RNA. 2011 Apr;17(4):639-51. doi: 10.1261/rna.2310111. Epub 2011 Feb 22. PMID: 21343388. Effect of life history on microRNA expression during C. elegans development.Karp X, Hammell M, Ow MC, Ambros V.RNA. 2011 Apr;17(4):639-51. doi: 10.1261/rna.2310111. Epub 2011 Feb 22. PMID: 21343388. The developmental timing regulator HBL-1 modulates the dauer formation decision in Caenorhabditis elegans.Karp X, Ambros V.Genetics. 2011 Jan;187(1):345-53. doi: 10.1534/genetics.110.123992. Epub 2010 Oct 26. PMID: 20980238. A feedback circuit involving let-7-family miRNAs and DAF-12 integrates environmental signals and developmental timing in Caenorhabditis elegans.Hammell CM, Karp X, Ambros V.Proc Natl Acad Sci U S A. 2009 Nov 3;106(44):18668-73. doi: 10.1073/pnas.0908131106. Epub 2009 Oct 14. PMID: 19828440. Developmental biology. Encountering microRNAs in cell fate signaling.Karp X, Ambros V.Science. 2005 Nov 25;310(5752):1288-9. PMID: 16311325. Multiple roles for the E/Daughterless ortholog HLH-2 during C. elegans gonadogenesis.Karp X, Greenwald I.Dev Biol. 2004 Aug 15;272(2):460-9. PMID: 15282161. Post-transcriptional regulation of the E/Daughterless ortholog HLH-2, negative feedback, and birth order bias during the AC/VU decision in C. elegans.Karp X, Greenwald I.Genes Dev. 2003 Dec 15;17(24):3100-11. PMID: 14701877. G2A is an oncogenic G protein-coupled receptor.Zohn IE, Klinger M, Karp X, Kirk H, Symons M, Chrzanowska-Wodnicka M, Der CJ, Kay RJ.Oncogene. 2000 Aug 10;19(34):3866-77. PMID: 10951580. Activation of SPARC expression in reactive stroma associated with human epithelial ovarian cancer.Brown TJ, Shaw PA, Karp X, Huynh MH, Begley H, Ringuette MJ.Gynecol Oncol. 1999 Oct;75(1):25-33. PMID: 10502421 Ectopic expression of SPARC in Xenopus embryos interferes with tissue morphogenesis: identification of a bioactive sequence in the C-terminal EF hand.Damjanovski S, Karp X, Funk S, Sage EH, Ringuette MJ.J Histochem Cytochem. 1997 May;45(5):643-55. PMID: 9154151.Funding
